| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Integrin linked ILK (350-452) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S6MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ILK |
| Gene ID: |
3611 |
| Uniprot ID: |
ILK_HUMAN |
| Immunogen Region: |
350-452 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 350-452 of human Integrin linked ILK (Q13418). |
| Immunogen Sequence: |
MYAPAWVAPEALQKKPEDTN RRSADMWSFAVLLWELVTRE VPFADLSNMEIGMKVALEGL RPTIPPGISPHVCKLMKICM NEDPAKRPKFDMIVPILEKM QDK |
| Tissue Specificity | Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver. |
| Post Translational Modifications | Autophosphorylated on serine residues. |
| Function | Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. |
| Protein Name | Integrin-Linked Protein Kinase59 Kda Serine/Threonine-Protein KinaseBeta-Integrin-Linked KinaseIlk-1Ilk-2P59ilk |
| Database Links | Reactome: R-HSA-446343Reactome: R-HSA-446353 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodiumCytoplasmMyofibrilSarcomere |
| Alternative Antibody Names | Anti-Integrin-Linked Protein Kinase antibodyAnti-59 Kda Serine/Threonine-Protein Kinase antibodyAnti-Beta-Integrin-Linked Kinase antibodyAnti-Ilk-1 antibodyAnti-Ilk-2 antibodyAnti-P59ilk antibodyAnti-ILK antibodyAnti-ILK1 antibodyAnti-ILK2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
