Anti-ADA antibody (250-350) [S6MR] (STJ11102276)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal ADA (250-350) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S6MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADA |
| Gene ID | 100 |
| Uniprot ID | ADA_HUMAN |
| Immunogen Region | 250-350 |
| Immunogen Sequence | NRLRQENMHFEICPWSSYLT GAWKPDTEHAVIRLKNDQAN YSLNTDDPLIFKSTLDTDYQ MTKRDMGFTEEEFKRLNINA AKSSFLPEDEKRELLDLLYK A |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human Adenosine Deaminase (ADA) (NP_000013.2). |
Additional Info
| Tissue Specificity | Found in all tissues, occurs in large amounts in T-lymphocytes. Expressed at the time of weaning in gastrointestinal tissues. |
| Function | Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion. Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion. Enhances CD4+ T-cell differentiation and proliferation. Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change. Stimulates plasminogen activation. Plays a role in male fertility. Plays a protective role in early postimplantation embryonic development. Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties. |
| Protein Name | Adenosine DeaminaseAdenosine Aminohydrolase |
| Database Links | Reactome: R-HSA-74217Reactome: R-HSA-9734735Reactome: R-HSA-9755088 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinExtracellular SideCell JunctionCytoplasmic Vesicle LumenCytoplasmLysosomeColocalized With Dpp4 At The Cell Surface |
| Alternative Antibody Names | Anti-Adenosine Deaminase antibodyAnti-Adenosine Aminohydrolase antibodyAnti-ADA antibodyAnti-ADA1 antibody |
Information sourced from Uniprot.org