| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL5RA |
| Gene ID: | 3568 |
| Uniprot ID: | IL5RA_HUMAN |
| Immunogen Region: | 20-335 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-335 of human IL5RA (NP_783855.1). |
| Immunogen Sequence: | ADLLPDEKISLLPPVNFTIK VTGLAQVLLQWKPNPDQEQR NVNLEYQVKINAPKEDDYET RITESKCVTILHKGFSASVR TILQNDHSLLASSWASAELH APPGSPGTSIVNLTCTTNTT EDNYSRLRSYQVSLHCTWLV GTDAPEDTQYFLYYRYGSWT EECQEYSKDTLGRNIACWFP RTFILSKGRDWLAVLVNGSS KHSAIRPFDQLFALHAIDQI NPPLNVTAEIEGTRLSIQW |
| Tissue Specificity | Expressed on eosinophils and basophils. |
| Function | Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway. |
| Protein Name | Interleukin-5 Receptor Subunit AlphaIl-5 Receptor Subunit AlphaIl-5r Subunit AlphaIl-5r-AlphaIl-5raCdw125Cd Antigen Cd125 |
| Database Links | Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-912526 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-5 Receptor Subunit Alpha antibodyAnti-Il-5 Receptor Subunit Alpha antibodyAnti-Il-5r Subunit Alpha antibodyAnti-Il-5r-Alpha antibodyAnti-Il-5ra antibodyAnti-Cdw125 antibodyAnti-Cd Antigen Cd125 antibodyAnti-IL5RA antibodyAnti-IL5R antibody |
Information sourced from Uniprot.org