| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL4R |
| Gene ID: | 3566 |
| Uniprot ID: | IL4RA_HUMAN |
| Immunogen Region: | 26-232 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-232 of human IL4R (NP_000409.1). |
| Immunogen Sequence: | MKVLQEPTCVSDYMSISTCE WKMNGPTNCSTELRLLYQLV FLLSEAHTCIPENNGGAGCV CHLLMDDVVSADNYTLDLWA GQQLLWKGSFKPSEHVKPRA PGNLTVHTNVSDTLLLTWSN PYPPDNYLYNHLTYAVNIWS ENDPADFRIYNVTYLEPSLR IAASTLKSGISYRARVRAWA QCYNTTWSEWSPSTKWHNSY REPFEQH |
| Tissue Specificity | Isoform 1 and isoform 2 are highly expressed in activated T-cells. |
| Post Translational Modifications | On IL4 binding, phosphorylated on C-terminal tyrosine residues. Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction. The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase. |
| Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. |
| Protein Name | Interleukin-4 Receptor Subunit Alpha Il-4 Receptor Subunit Alpha Il-4r Subunit Alpha Il-4r-Alpha Il-4ra Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha Soluble Il-4 Receptor Subunit Alpha Soluble Il-4r-Alpha Sil4ralpha/Prot Il-4-Binding Protein Il4-Bp |
| Database Links | Reactome: R-HSA-6785807 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted |
| Alternative Antibody Names | Anti-Interleukin-4 Receptor Subunit Alpha antibody Anti-Il-4 Receptor Subunit Alpha antibody Anti-Il-4r Subunit Alpha antibody Anti-Il-4r-Alpha antibody Anti-Il-4ra antibody Anti-Cd Antigen Cd124 Cleaved Into - Soluble Interleukin-4 Receptor Subunit Alpha antibody Anti-Soluble Il-4 Receptor Subunit Alpha antibody Anti-Soluble Il-4r-Alpha antibody Anti-Sil4ralpha/Prot antibody Anti-Il-4-Binding Protein antibody Anti-Il4-Bp antibody Anti-IL4R antibody Anti-IL4RA antibody Anti-582J2.1 antibody |
Information sourced from Uniprot.org