| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5162RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL26 |
| Gene ID: | 55801 |
| Uniprot ID: | IL26_HUMAN |
| Immunogen Region: | 50-154 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 50-154 of human IL26 (NP_060872.1). |
| Immunogen Sequence: | AWLKATIPEDRIKNIRLLKK KTKKQFMKNCQFQEQLLSFF MEDVFGQLQLQGCKKIRFVE DFHSLRQKLSHCISCASSAR EMKSITRMKRIFYRIGNKGI YKAIS |
| Tissue Specificity | Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells.the expression is significantly increased in serum of patients with Crohn's disease (at protein level). |
| Function | May play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. |
| Protein Name | Interleukin-26Il-26Protein Ak155 |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-26 antibodyAnti-Il-26 antibodyAnti-Protein Ak155 antibodyAnti-IL26 antibodyAnti-AK155 antibody |
Information sourced from Uniprot.org
