| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Interleukin-26 (50-154) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5162RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL26 |
| Gene ID: |
55801 |
| Uniprot ID: |
IL26_HUMAN |
| Immunogen Region: |
50-154 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 50-154 of human IL26 (NP_060872.1). |
| Immunogen Sequence: |
AWLKATIPEDRIKNIRLLKK KTKKQFMKNCQFQEQLLSFF MEDVFGQLQLQGCKKIRFVE DFHSLRQKLSHCISCASSAR EMKSITRMKRIFYRIGNKGI YKAIS |
| Tissue Specificity | Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells.the expression is significantly increased in serum of patients with Crohn's disease (at protein level). |
| Function | May play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. |
| Protein Name | Interleukin-26Il-26Protein Ak155 |
| Database Links | Reactome: R-HSA-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-26 antibodyAnti-Il-26 antibodyAnti-Protein Ak155 antibodyAnti-IL26 antibodyAnti-AK155 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
