| Post Translational Modifications | Glycosylated. Ubiquitination at Lys-97 promotes proteasomal degradation. |
| Function | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2. |
| Protein Name | Interleukin-24Il-24Il-4-Induced Secreted ProteinMelanoma Differentiation-Associated Gene 7 ProteinMda-7Th2-Specific Cytokine Fisp |
| Database Links | Reactome: R-MMU-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-24 antibodyAnti-Il-24 antibodyAnti-Il-4-Induced Secreted Protein antibodyAnti-Melanoma Differentiation-Associated Gene 7 Protein antibodyAnti-Mda-7 antibodyAnti-Th2-Specific Cytokine Fisp antibodyAnti-Il24 antibodyAnti-Mda7 antibody |
Information sourced from Uniprot.org
