Anti-IL24 antibody [Fs0358] (STJA0032143)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
General Information
| Short Description | Mouse monoclonal anti-IL24 for use in ELISA, FCM and Neut in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FCM/Neut |
| Host | Mouse |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | Fs0358 |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | Il24 |
| Gene ID | 93672 |
| Uniprot ID | IL24_MOUSE |
Additional Info
| Post Translational Modifications | Glycosylated. Ubiquitination at Lys-97 promotes proteasomal degradation. |
| Function | Multifunctional cytokine mainly produced by T-cells that plays a regulatory role in immune response, tissue homeostasis, host defense, and oncogenesis. Possesses antiviral functions and induces the type I interferon response during influenza infection. Signals through two receptor complexes IL20RA/IL20RB or IL20RB/IL22RA1. In turn, stimulates the JAK1-STAT3 and MAPK pathways and promotes the secretion of pro-inflammatory mediators including IL8 and MMP1. Intracellularly, maintains endoplasmic reticulum homeostasis by restricting the eIF2alpha-CHOP pathway-mediated stress signal. In addition, acts as a quality control mechanism for the ubiquitin proteasome system by alerting the cell to proteasome dysfunction through activation of PKR/EIF2AK2. |
| Protein Name | Interleukin-24Il-24Il-4-Induced Secreted ProteinMelanoma Differentiation-Associated Gene 7 ProteinMda-7Th2-Specific Cytokine Fisp |
| Database Links | Reactome: R-MMU-8854691 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interleukin-24 antibodyAnti-Il-24 antibodyAnti-Il-4-Induced Secreted Protein antibodyAnti-Melanoma Differentiation-Associated Gene 7 Protein antibodyAnti-Mda-7 antibodyAnti-Th2-Specific Cytokine Fisp antibodyAnti-Il24 antibodyAnti-Mda7 antibody |
Information sourced from Uniprot.org