| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IL1R2 (20-320) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IL1R2 |
| Gene ID: |
7850 |
| Uniprot ID: |
IL1R2_HUMAN |
| Immunogen Region: |
20-320 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human IL1R2 (NP_775465.1). |
| Immunogen Sequence: |
AHTGAARSCRFRGRHYKREF RLEGEPVALRCPQVPYWLWA SVSPRINLTWHKNDSARTVP GEEETRMWAQDGALWLLPAL QEDSGTYVCTTRNASYCDKM SIELRVFENTDAFLPFISYP QILTLSTSGVLVCPDLSEFT RDKTDVKIQWYKDSLLLDKD NEKFLSVRGTTHLLVHDVAL EDAGYYRCVLTFAHEGQQYN ITRSIELRIKKKKEETIPVI ISPLKTISASLGSRLTIPC |
| Post Translational Modifications | A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase.hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported. |
| Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
| Protein Name | Interleukin-1 Receptor Type 2Il-1r-2Il-1rt-2Il-1rt2Cd121 Antigen-Like Family Member BCdw121bIl-1 Type Ii ReceptorInterleukin-1 Receptor BetaIl-1r-BetaInterleukin-1 Receptor Type IiCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane FormMil-1r2Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble FormSil-1r2Sil-1rii |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702 |
| Cellular Localisation | Isoform Short: SecretedIsoform Long: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor Type 2 antibodyAnti-Il-1r-2 antibodyAnti-Il-1rt-2 antibodyAnti-Il-1rt2 antibodyAnti-Cd121 Antigen-Like Family Member B antibodyAnti-Cdw121b antibodyAnti-Il-1 Type Ii Receptor antibodyAnti-Interleukin-1 Receptor Beta antibodyAnti-Il-1r-Beta antibodyAnti-Interleukin-1 Receptor Type Ii antibodyAnti-Cd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form antibodyAnti-Mil-1r2 antibodyAnti-Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form antibodyAnti-Sil-1r2 antibodyAnti-Sil-1rii antibodyAnti-IL1R2 antibodyAnti-IL1RB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
