Anti-IL1R2 antibody (141-190 aa) (STJ96835)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human IL1R2 at the amino acid range 141-190
General Information
| Short Description | Rabbit polyclonal anti-Interleukin-1 receptor type 2 (141-190 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IL1R2 |
| Gene ID | 7850 |
| Uniprot ID | IL1R2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human IL1R2 at the amino acid range 141-190 |
| Immunogen Region | 141-190 aa |
| Specificity | IL-1RII Polyclonal Antibody detects endogenous levels of IL-1RII protein. |
Additional Info
| Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. |
| Protein Name | Interleukin-1 Receptor Type 2Il-1r-2Il-1rt-2Il-1rt2Cd121 Antigen-Like Family Member BCdw121bIl-1 Type Ii ReceptorInterleukin-1 Receptor BetaIl-1r-BetaInterleukin-1 Receptor Type IiCd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane FormMil-1r2Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble FormSil-1r2Sil-1rii |
| Database Links | Reactome: R-HSA-6783783Reactome: R-HSA-9020702 |
| Cellular Localisation | Isoform Short: SecretedIsoform Long: Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor Type 2 antibodyAnti-Il-1r-2 antibodyAnti-Il-1rt-2 antibodyAnti-Il-1rt2 antibodyAnti-Cd121 Antigen-Like Family Member B antibodyAnti-Cdw121b antibodyAnti-Il-1 Type Ii Receptor antibodyAnti-Interleukin-1 Receptor Beta antibodyAnti-Il-1r-Beta antibodyAnti-Interleukin-1 Receptor Type Ii antibodyAnti-Cd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form antibodyAnti-Mil-1r2 antibodyAnti-Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form antibodyAnti-Sil-1r2 antibodyAnti-Sil-1rii antibodyAnti-IL1R2 antibodyAnti-IL1RB antibody |
Information sourced from Uniprot.org