| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL12RB2 |
| Gene ID: | 3595 |
| Uniprot ID: | I12R2_HUMAN |
| Immunogen Region: | 420-620 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-620 of human IL12RB2 (NP_001550.1). |
| Immunogen Sequence: | GLLAPRQVSANSEGMDNILV TWQPPRKDPSAVQEYVVEWR ELHPGGDTQVPLNWLRSRPY NVSALISENIKSYICYEIRV YALSGDQGGCSSILGNSKHK APLSGPHINAITEEKGSILI SWNSIPVQEQMGCLLHYRIY WKERDSNSQPQLCEIPYRVS QNSHPINSLQPRVTYVLWMT ALTAAGESSHGNEREFCLQG K |
| Tissue Specificity | Isoform 2 is expressed at similar levels in both naive and activated T-cells. |
| Post Translational Modifications | On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding. |
| Function | Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. |
| Protein Name | Interleukin-12 Receptor Subunit Beta-2Il-12 Receptor Subunit Beta-2Il-12r Subunit Beta-2Il-12r-Beta-2Il-12rb2 |
| Database Links | Reactome: R-HSA-8984722Reactome: R-HSA-9020591 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-12 Receptor Subunit Beta-2 antibodyAnti-Il-12 Receptor Subunit Beta-2 antibodyAnti-Il-12r Subunit Beta-2 antibodyAnti-Il-12r-Beta-2 antibodyAnti-Il-12rb2 antibodyAnti-IL12RB2 antibody |
Information sourced from Uniprot.org