![Anti-IL12RB2 nanobody [SAA1301] (STJN000297)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200910/413092/STJN000297-SDS-PAGE-1__06137.1749232595.jpg?c=1 "Anti-IL12RB2 nanobody [SAA1301] (STJN000297)")
![Anti-IL12RB2 nanobody [SAA1301] (STJN000297)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200910/413092/STJN000297-SDS-PAGE-1__06137.1749232595.jpg?c=1 "Anti-IL12RB2 nanobody [SAA1301] (STJN000297)")
Anti-IL12RB2 nanobody [SAA1301] (STJN000297)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Interleukin-12 Receptor Subunit Beta-2 is suitable for use in ELISA, Flow Cytometry and SPR research applications. |
| Applications | ELISA/FC/SPR |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1301 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | IL12RB2 |
| Gene ID | 3595 |
| Uniprot ID | I12R2_HUMAN |
Additional Info
| Post Translational Modifications | On IL12 binding, phosphorylated on C-terminal tyrosine residues by JAK2. Phosphorylation on Tyr-800 is required for STAT4 binding and activation, and for SOCS3 binding. |
| Function | Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells. Induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production. |
| Protein Name | Interleukin-12 Receptor Subunit Beta-2Il-12 Receptor Subunit Beta-2Il-12r Subunit Beta-2Il-12r-Beta-2Il-12rb2 |
| Database Links | Reactome: R-HSA-8984722Reactome: R-HSA-9020591 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Nanobody Names | Anti-Interleukin-12 Receptor Subunit Beta-2 nanobodyAnti-Il-12 Receptor Subunit Beta-2 nanobodyAnti-Il-12r Subunit Beta-2 nanobodyAnti-Il-12r-Beta-2 nanobodyAnti-Il-12rb2 nanobodyAnti-IL12RB2 nanobody |
Information sourced from Uniprot.org