| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IL12RB1 |
| Gene ID: | 3594 |
| Uniprot ID: | I12R1_HUMAN |
| Immunogen Region: | 25-305 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-305 of human IL12RB1 (NP_714912.1). |
| Immunogen Sequence: | RTSECCFQDPPYPDADSGSA SGPRDLRCYRISSDRYECSW QYEGPTAGVSHFLRCCLSSG RCCYFAAGSATRLQFSDQAG VSVLYTVTLWVESWARNQTE KSPEVTLQLYNSVKYEPPLG DIKVSKLAGQLRMEWETPDN QVGAEVQFRHRTPSSPWKLG DCGPQDDDTESCLCPLEMNV AQEFQLRRRQLGSQGSSWSK WSSPVCVPPENPPQPQVRFS VEQLGQDGRRRLTLKEQPT |
| Function | Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. |
| Protein Name | Interleukin-12 Receptor Subunit Beta-1Il-12 Receptor Subunit Beta-1Il-12r Subunit Beta-1Il-12r-Beta-1Il-12rb1Il-12 Receptor Beta ComponentCd Antigen Cd212 |
| Database Links | Reactome: R-HSA-9020591Reactome: R-HSA-9020933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interleukin-12 Receptor Subunit Beta-1 antibodyAnti-Il-12 Receptor Subunit Beta-1 antibodyAnti-Il-12r Subunit Beta-1 antibodyAnti-Il-12r-Beta-1 antibodyAnti-Il-12rb1 antibodyAnti-Il-12 Receptor Beta Component antibodyAnti-Cd Antigen Cd212 antibodyAnti-IL12RB1 antibodyAnti-IL12R antibodyAnti-IL12RB antibody |
Information sourced from Uniprot.org