| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
Il1rl1 |
| Gene ID: |
17082 |
| Uniprot ID: |
ILRL1_MOUSE |
| Immunogen Region: |
27-332 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 27-332 of mouse IL-33R (ST2) (NP_001020773.1). |
| Immunogen Sequence: |
SKSSWGLENEALIVRCPQRG RSTYPVEWYYSDTNESIPTQ KRNRIFVSRDRLKFLPARVE DSGIYACVIRSPNLNKTGYL NVTIHKKPPSCNIPDYLMYS TVRGSDKNFKITCPTIDLYN WTAPVQWFKNCKALQEPRFR AHRSYLFIDNVTHDDEGDYT CQFTHAENGTNYIVTATRSF TVEEKGFSMFPVITNPPYNH TMEVEIGKPASIACSACFGK GSHFLADVLWQINKTVVGN |
| Tissue Specificity | Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines. Isoform A is expressed in brain astrocytes and microglia. Isoform B is expressed in brain endothelial cells. |
| Post Translational Modifications | Phosphorylated by GSK3B at Ser-442.leading to proteasomal degradation. Ubiquitinated at Lys-326 in a FBXL19-mediated manner.leading to proteasomal degradation. Ubiquitination by TRAF6 via 'Lys-27'-linked polyubiquitination and deubiquitination by USP38 serves as a critical regulatory mechanism for fine-tuning IL1RL1-mediated inflammatory response. |
| Function | Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. Isoform B: Inhibits IL-33 signaling. |
| Protein Name | Interleukin-1 Receptor-Like 1Interleukin-33 Receptor Alpha ChainLymphocyte Antigen 84Protein St2Protein T1 |
| Database Links | Reactome: R-MMU-1257604Reactome: -MMU-6811558Reactome: -MMU-9014843 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform B: Secreted |
| Alternative Antibody Names | Anti-Interleukin-1 Receptor-Like 1 antibodyAnti-Interleukin-33 Receptor Alpha Chain antibodyAnti-Lymphocyte Antigen 84 antibodyAnti-Protein St2 antibodyAnti-Protein T1 antibodyAnti-Il1rl1 antibodyAnti-Ly84 antibodyAnti-St2 antibodyAnti-Ste2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
