| Function | Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA. May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK). |
| Protein Name | Elongator Complex Protein 1Elp1Ikappab Kinase Complex-Associated ProteinIkk Complex-Associated ProteinP150 |
| Database Links | Reactome: R-HSA-3214847 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Elongator Complex Protein 1 antibodyAnti-Elp1 antibodyAnti-Ikappab Kinase Complex-Associated Protein antibodyAnti-Ikk Complex-Associated Protein antibodyAnti-P150 antibodyAnti-ELP1 antibodyAnti-IKAP antibodyAnti-IKBKAP antibody |
Information sourced from Uniprot.org
