Host: |
Rabbit |
Applications: |
WB/IHC/IF/ELISA |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-Protein Red (508-557 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
IK |
Gene ID: |
3550 |
Uniprot ID: |
RED_HUMAN |
Immunogen Region: |
508-557 aa |
Specificity: |
IK Polyclonal Antibody detects endogenous levels of IK protein. |
Immunogen: |
The antiserum was produced against synthesized peptide derived from the human RED at the amino acid range 508-557 |
Function | Involved in pre-mRNA splicing as a component of the spliceosome. Auxiliary spliceosomal protein that regulates selection of alternative splice sites in a small set of target pre-mRNA species (Probable). Required for normal mitotic cell cycle progression. Recruits MAD1L1 and MAD2L1 to kinetochores, and is required to trigger the spindle assembly checkpoint. Required for normal accumulation of SMU1. (Microbial infection) Required, together with SMU1, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. |
Protein Name | Protein RedCytokine IkIk FactorProtein Rer |
Database Links | Reactome: R-HSA-72163 |
Cellular Localisation | NucleusNucleoplasmChromosomeCytoplasmCytoskeletonSpindle PolePredominantly Present Throughout The Nucleoplasm During PrometaphaseMetaphase And AnaphaseIs Also Detected In Nuclear Foci That Are Not Identical With Cajal BodiesStarts To Accumulate At Chromosomes During TelophaseAnd Is Nearly Exclusively Associated With Chromosomes In Newly Divided CellsColocalizes With Mad1l1 At Mitotic Spindle Poles During Metaphase And Anaphase |
Alternative Antibody Names | Anti-Protein Red antibodyAnti-Cytokine Ik antibodyAnti-Ik Factor antibodyAnti-Protein Rer antibodyAnti-IK antibodyAnti-RED antibodyAnti-RER antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance