| Host: | Mouse |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Insulin-like growth factor 2 mRNA-binding protein 3 is suitable for use in Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 1F1-E10-D11 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IGF2BP3 |
| Gene ID: | 10643 |
| Uniprot ID: | IF2B3_HUMAN |
| Specificity: | This antibody detects endogenous levels of IMP3 and does not cross-react with related proteins. |
| Immunogen: | Purified recombinant human IMP3 protein fragments expressed in E.coli. |
| Function | RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. |
| Protein Name | Insulin-Like Growth Factor 2 Mrna-Binding Protein 3 Igf2 Mrna-Binding Protein 3 Imp-3 Igf-Ii Mrna-Binding Protein 3 Kh Domain-Containing Protein Overexpressed In Cancer Hkoc Vickz Family Member 3 |
| Database Links | Reactome: R-HSA-428359 |
| Cellular Localisation | Nucleus Cytoplasm P-Body Stress Granule Found In Lamellipodia Of The Leading Edge In The Perinuclear Region And Beneath The Plasma Membrane The Subcytoplasmic Localization Is Cell Specific And Regulated By Cell Contact And Growth Localized At The Connecting Piece And The Tail Of The Spermatozoa Colocalized With Cd44 Mrna In Rnp Granules In Response To Cellular Stress Such As Oxidative Stress Recruited To Stress Granules |
| Alternative Antibody Names | Anti-Insulin-Like Growth Factor 2 Mrna-Binding Protein 3 antibody Anti-Igf2 Mrna-Binding Protein 3 antibody Anti-Imp-3 antibody Anti-Igf-Ii Mrna-Binding Protein 3 antibody Anti-Kh Domain-Containing Protein Overexpressed In Cancer antibody Anti-Hkoc antibody Anti-Vickz Family Member 3 antibody Anti-IGF2BP3 antibody Anti-IMP3 antibody Anti-KOC1 antibody Anti-VICKZ3 antibody |
Information sourced from Uniprot.org