| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IFT81 |
| Gene ID: | 28981 |
| Uniprot ID: | IFT81_HUMAN |
| Immunogen Region: | 550-676 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-676 of human IFT81 (NP_054774.2). |
| Immunogen Sequence: | VRRLREECLQEESRYHYTNC MIKNLEVQLRRATDEMKAYI SSDQQEKRKAIREQYTKNTA EQENLGKKLREKQKVIRESH GPNMKQAKMWRDLEQLMECK KQCFLKQQSQTSIGQVIQEG GEDRLIL |
| Tissue Specificity | Highly expressed in testis, moderately in ovary, heart, liver, skeletal muscle, kidney and pancreas, low in prostate, brain, placenta and lung and not detected in spleen, thymus, small intestine and colon. Isoform CDV-1R is abundantly expressed in testis. |
| Function | Component of the intraflagellar transport (IFT) complex B: together with IFT74, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds tubulin via its CH (calponin-homology)-like region. Required for ciliogenesis. Required for proper regulation of SHH signaling. Plays an important role during spermatogenesis by modulating the assembly and elongation of the sperm flagella. |
| Protein Name | Intraflagellar Transport Protein 81 Homolog Carnitine Deficiency-Associated Protein Expressed In Ventricle 1 Cdv-1 |
| Database Links | Reactome: R-HSA-5620924 |
| Cellular Localisation | Cell Projection Cilium Cytoplasm |
| Alternative Antibody Names | Anti-Intraflagellar Transport Protein 81 Homolog antibody Anti-Carnitine Deficiency-Associated Protein Expressed In Ventricle 1 antibody Anti-Cdv-1 antibody Anti-IFT81 antibody Anti-CDV1 antibody |
Information sourced from Uniprot.org
