| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-IFT57 (170-429) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
IFT57 |
| Gene ID: |
55081 |
| Uniprot ID: |
IFT57_HUMAN |
| Immunogen Region: |
170-429 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 170-429 of human IFT57 (NP_060480.1). |
| Immunogen Sequence: |
VEELEEESVAEDDAELTLNK VDEEFVEEETDNEENFIDLN VLKAQTYHLDMNETAKQEDI LESTTDAAEWSLEVERVLPQ LKVTIRTDNKDWRIHVDQMH QHRSGIESALKETKGFLDKL HNEITRTLEKISSREKYINN QLENLVQEYRAAQAQLSEAK ERYQQGNGGVTERTRLLSEV MEELEKVKQEMEEKGSSMTD GAPLVKIKQSLTKLKQETVE MDIRIGIVEHTLLQSKLKE |
| Tissue Specificity | Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level). |
| Function | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator.however the relevance of such function remains unclear. |
| Protein Name | Intraflagellar Transport Protein 57 HomologDermal Papilla-Derived Protein 8Estrogen-Related Receptor Beta-Like Protein 1Hip1-Interacting ProteinMhs4r2 |
| Database Links | Reactome: R-HSA-5610787Reactome: R-HSA-5620924 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyConcentrates Within The Inner Segment Of Cilia |
| Alternative Antibody Names | Anti-Intraflagellar Transport Protein 57 Homolog antibodyAnti-Dermal Papilla-Derived Protein 8 antibodyAnti-Estrogen-Related Receptor Beta-Like Protein 1 antibodyAnti-Hip1-Interacting Protein antibodyAnti-Mhs4r2 antibodyAnti-IFT57 antibodyAnti-DERP8 antibodyAnti-ESRRBL1 antibodyAnti-HIPPI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
