| Post Translational Modifications | Ubiquitinated by FBXO45-containing E3 ligase leading to proteasomal degradation. |
| Function | The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. |
| Protein Name | Interferon Lambda Receptor 1Ifn-Lambda Receptor 1Ifn-Lambda-R1Cytokine Receptor Class-Ii Member 12Cytokine Receptor Family 2 Member 12Crf2-12Interleukin-28 Receptor Subunit AlphaIl-28 Receptor Subunit AlphaIl-28r-AlphaIl-28raLikely Interleukin Or Cytokine Receptor 2Licr2 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-8854691 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Interferon Lambda Receptor 1 antibodyAnti-Ifn-Lambda Receptor 1 antibodyAnti-Ifn-Lambda-R1 antibodyAnti-Cytokine Receptor Class-Ii Member 12 antibodyAnti-Cytokine Receptor Family 2 Member 12 antibodyAnti-Crf2-12 antibodyAnti-Interleukin-28 Receptor Subunit Alpha antibodyAnti-Il-28 Receptor Subunit Alpha antibodyAnti-Il-28r-Alpha antibodyAnti-Il-28ra antibodyAnti-Likely Interleukin Or Cytokine Receptor 2 antibodyAnti-Licr2 antibodyAnti-IFNLR1 antibodyAnti-IL28RA antibodyAnti-LICR2 antibody |
Information sourced from Uniprot.org
