| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-IFN-beta (1-182) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4936RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:2000-1:7000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Ifnb1 |
| Gene ID: |
15977 |
| Uniprot ID: |
IFNB_MOUSE |
| Immunogen Region: |
1-182 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-182 of mouse IFN-beta (NP_034640.1) |
| Immunogen Sequence: |
MNNRWILHAAFLLCFSTTAL SINYKQLQLQERTNIRKCQE LLEQLNGKINLTYRADFKIP MEMTEKMQKSYTAFAIQEML QNVFLVFRNNFSSTGWNETI VVRLLDELHQQTVFLKTVLE EKQEERLTWEMSSTALHLKS YYWRVQRYLKLMKYNSYAWM VVRAEIFRNFLIIRRLTRNF QN |
| Post Translational Modifications | This beta interferon does not have a disulfide bond. |
| Function | Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth. |
| Protein Name | Interferon BetaIfn-Beta |
| Database Links | Reactome: R-MMU-909733Reactome: -MMU-912694 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interferon Beta antibodyAnti-Ifn-Beta antibodyAnti-Ifnb1 antibodyAnti-Ifb antibodyAnti-Ifnb antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
