Anti-IFN-beta antibody (1-182 aa) [SRM5227] (STJ11107109)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal IFN-beta (1-182 aa) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5227 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:4000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Ifnb1 |
| Gene ID | 15977 |
| Uniprot ID | IFNB_MOUSE |
| Immunogen Region | 1-182 aa |
| Immunogen Sequence | MNNRWILHAAFLLCFSTTAL SINYKQLQLQERTNIRKCQE LLEQLNGKINLTYRADFKIP MEMTEKMQKSYTAFAIQEML QNVFLVFRNNFSSTGWNETI VVRLLDELHQQTVFLKTVLE EKQEERLTWEMSSTALHLKS YYWRVQRYLKLMKYNSYAWM VVRAEIFRNFLIIRRLTRNF QN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-182 of mouse IFN-beta (NP_034640.1) |
Additional Info
| Post Translational Modifications | This beta interferon does not have a disulfide bond. |
| Function | Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth. |
| Protein Name | Interferon BetaIfn-Beta |
| Database Links | Reactome: R-MMU-909733Reactome: -MMU-912694 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Interferon Beta antibodyAnti-Ifn-Beta antibodyAnti-Ifnb1 antibodyAnti-Ifb antibodyAnti-Ifnb antibody |
Information sourced from Uniprot.org