| Function | Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E. Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro. Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families. |
| Protein Name | Antiviral Innate Immune Response Effector Ifit1Ifit-1Interferon-Induced 56 Kda ProteinIfi-56kP56Interferon-Induced Protein With Tetratricopeptide Repeats 1 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-909733 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Antiviral Innate Immune Response Effector Ifit1 antibodyAnti-Ifit-1 antibodyAnti-Interferon-Induced 56 Kda Protein antibodyAnti-Ifi-56k antibodyAnti-P56 antibodyAnti-Interferon-Induced Protein With Tetratricopeptide Repeats 1 antibodyAnti-IFIT1 antibodyAnti-G10P1 antibodyAnti-IFI56 antibodyAnti-IFNAI1 antibodyAnti-ISG56 antibody |
Information sourced from Uniprot.org
