• Western blot analysis of lysates from LOVO cells, using IFIT1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

Anti-IFIT1 antibody (41-90 aa) (STJ93640)

SKU:
STJ93640

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Interferon-induced protein with tetratricopeptide repeats 1 (41-90 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: IFIT1
Gene ID: 3434
Uniprot ID: IFIT1_HUMAN
Immunogen Region: 41-90 aa
Specificity: IFI-56K Polyclonal Antibody detects endogenous levels of IFI-56K protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human IFIT1 at the amino acid range 41-90
Function Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
Protein Name Interferon-Induced Protein With Tetratricopeptide Repeats 1
Ifit-1
Interferon-Induced 56 Kda Protein
Ifi-56k
P56
Database Links Reactome: R-HSA-1169408
Reactome: R-HSA-909733
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Interferon-Induced Protein With Tetratricopeptide Repeats 1 antibody
Anti-Ifit-1 antibody
Anti-Interferon-Induced 56 Kda Protein antibody
Anti-Ifi-56k antibody
Anti-P56 antibody
Anti-IFIT1 antibody
Anti-G10P1 antibody
Anti-IFI56 antibody
Anti-IFNAI1 antibody
Anti-ISG56 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance