Anti-Iduronate 2-Sulfatase/IDS antibody (26-550aa) [AT6H4] (STJA0041886)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenRecombinant human IDS (26-550aa) purified from insect cell
General Information
| Short Description | Mouse monoclonal anti-Iduronate 2-Sulfatase/IDS (26-550aa) for use in ELISA, WB and FACS in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/FACS |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT6H4 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | IDS |
| Gene ID | 3423 |
| Uniprot ID | IDS_HUMAN |
| Accession Number | NP_000193 |
| Immunogen | Recombinant human IDS (26-550aa) purified from insect cell |
| Immunogen Region | 26-550aa |
Additional Info
| Tissue Specificity | Liver, kidney, lung, and placenta. |
| Post Translational Modifications | Synthesized as a 75-kDa precursor form in the endoplasmic reticulum (ER), and then processed by proteolytic cleavage through various intermediates to yield a 55-kDa mature form, with the release of an 18 kDa polypeptide. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. |
| Function | Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. |
| Protein Name | Iduronate 2-SulfataseAlpha-L-Iduronate Sulfate SulfataseIdursulfase Cleaved Into - Iduronate 2-Sulfatase 42 Kda Chain - Iduronate 2-Sulfatase 14 Kda Chain |
| Database Links | Reactome: R-HSA-2024096Reactome: R-HSA-2024101Reactome: R-HSA-2206296 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Iduronate 2-Sulfatase antibodyAnti-Alpha-L-Iduronate Sulfate Sulfatase antibodyAnti-Idursulfase Cleaved Into - Iduronate 2-Sulfatase 42 Kda Chain - Iduronate 2-Sulfatase 14 Kda Chain antibodyAnti-IDS antibodyAnti-SIDS antibody |
Information sourced from Uniprot.org