| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Icam1 |
| Gene ID: | 25464 |
| Uniprot ID: | ICAM1_RAT |
| Immunogen Region: | 28-493 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-493 of rat Icam1. (NP_037099.1). |
| Immunogen Sequence: | QVSIHPTEAFLPRGGSVQVN CSSSCEDENLGLGLETNWMK DELSSGHNWKLFKLSDIGED SRPLCFENCGTTQSSASATI TVYSFPERVELDPLPAWQQV GKNLILRCLVEGGAPRTQLS VVLLRGNETLSRQAVDGDPK EITFTVLASRGDHGANFSCF TELDLRPQGLSLFKNVSEVR QLRTFDLPTRVLKLDTPDLL EVGTQQKFLCSLEGLFPASE AQIYLEMGGQMLTLESTNS |
| Post Translational Modifications | Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. |
| Protein Name | Intercellular Adhesion Molecule 1 Icam-1 Cd Antigen Cd54 |
| Database Links | Reactome: R-RNO-198933 Reactome: -RNO-216083 |
| Cellular Localisation | Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Intercellular Adhesion Molecule 1 antibody Anti-Icam-1 antibody Anti-Cd Antigen Cd54 antibody Anti-Icam1 antibody Anti-Icam-1 antibody |
Information sourced from Uniprot.org