| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Icam1 |
| Gene ID: | 15894 |
| Uniprot ID: | ICAM1_MOUSE |
| Immunogen Region: | 120-320 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-320 of mouse ICAM1 (NP_034623.1). |
| Immunogen Sequence: | LPAWQQVGKDLTLRCHVDGG APRTQLSAVLLRGEEILSRQ PVGGHPKDPKEITFTVLASR GDHGANFSCRTELDLRPQGL ALFSNVSEARSLRTFDLPAT IPKLDTPDLLEVGTQQKLFC SLEGLFPASEARIYLELGGQ MPTQESTNSSDSVSATALVE VTEEFDRTLPLRCVLELADQ ILETQRTLTVYNFSAPVLTL S |
| Tissue Specificity | Expressed at low level on a subpopulation of lymphocytes, macrophages, and endothelial cells, but is strongly induced on these cells, and on fibroblasts and epithelial cells. |
| Post Translational Modifications | Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. |
| Protein Name | Intercellular Adhesion Molecule 1Icam-1Mala-2Myd10Cd Antigen Cd54 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-216083 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Intercellular Adhesion Molecule 1 antibodyAnti-Icam-1 antibodyAnti-Mala-2 antibodyAnti-Myd10 antibodyAnti-Cd Antigen Cd54 antibodyAnti-Icam1 antibodyAnti-Icam-1 antibody |
Information sourced from Uniprot.org
