| Host: |
Rabbit |
| Applications: |
IHC-F/ELISA/IP/WB |
| Reactivity: |
Human/Baboon/Chimpanzee/Cynomolgus Monkey/Rhesus |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ICAM-1 is suitable for use in Immunohistochemistry, ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
Ig |
| Formulation: |
PBS with 0.1% BSA and 0.02% sodium azide |
| Purification: |
Affinity purified |
| Concentration: |
50 ug/mL |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Post Translational Modifications | Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. |
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. |
| Protein Name | Intercellular Adhesion Molecule 1Icam-1Major Group Rhinovirus ReceptorCd Antigen Cd54 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-216083Reactome: R-HSA-6783783Reactome: R-HSA-6785807Reactome: R-HSA-877300 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Intercellular Adhesion Molecule 1 antibodyAnti-Icam-1 antibodyAnti-Major Group Rhinovirus Receptor antibodyAnti-Cd Antigen Cd54 antibodyAnti-ICAM1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Anti-ICAM-1 antibody [MEM 111] (STJ16100067)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/148785/346515/STJ16100067_1__54126.1681998545.jpg?c=1 "Anti-ICAM-1 antibody [MEM 111] (STJ16100067)")