| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Inhibitor of Bruton tyrosine kinase (410-490 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IBTK |
| Gene ID: | 25998 |
| Uniprot ID: | IBTK_HUMAN |
| Immunogen Region: | 410-490 aa |
| Specificity: | IBTK Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 410-490 |
| Function | Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. |
| Protein Name | Inhibitor Of Bruton Tyrosine KinaseIbtk |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinTranslocates To The Plasma Membrane Upon Igm StimulationIsoform 2: Nucleus |
| Alternative Antibody Names | Anti-Inhibitor Of Bruton Tyrosine Kinase antibodyAnti-Ibtk antibodyAnti-IBTK antibodyAnti-BTKI antibodyAnti-KIAA1417 antibody |
Information sourced from Uniprot.org