| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Islet amyloid polypeptide (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | IAPP |
| Gene ID: | 3375 |
| Uniprot ID: | IAPP_HUMAN |
| Immunogen Region: | 1-50 aa |
| Specificity: | Amylin Polyclonal Antibody detects endogenous levels of Amylin protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Amylin at the amino acid range 1-50 |
| Function | Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis. Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes. Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs. |
| Protein Name | Islet Amyloid PolypeptideIappAmylinDiabetes-Associated PeptideDapInsulinoma Amyloid Peptide |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-418555Reactome: R-HSA-419812Reactome: R-HSA-977225 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Islet Amyloid Polypeptide antibodyAnti-Iapp antibodyAnti-Amylin antibodyAnti-Diabetes-Associated Peptide antibodyAnti-Dap antibodyAnti-Insulinoma Amyloid Peptide antibodyAnti-IAPP antibody |
Information sourced from Uniprot.org