Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Basement membrane-specific heparan sulfate proteoglycan core protein is suitable for use in Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | HSPG2 |
Gene ID: | 3339 |
Uniprot ID: | PGBM_HUMAN |
Specificity: | This antibody detects endogenous levels of HSPG2 at Human, Mouse |
Immunogen: | Synthesized peptide derived from human HSPG2 |
Post Translational Modifications | Proteolytic processing produces the C-terminal angiogenic peptide, endorepellin. This peptide can be further processed to produce the LG3 peptide. O-glycosylated with core 1 or possibly core 8 glycans. Contains three heparan sulfate chains. Also contains chondroitin sulfate. |
Function | Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development. Endorepellin: Anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6. LG3 peptide: Has anti-angiogenic properties that require binding of calcium ions for full activity. |
Protein Name | Basement Membrane-Specific Heparan Sulfate Proteoglycan Core Protein Hspg Perlecan Plc Cleaved Into - Endorepellin - Lg3 Peptide |
Database Links | Reactome: R-HSA-1474228 Reactome: R-HSA-1971475 Reactome: R-HSA-2022928 Reactome: R-HSA-2024096 Reactome: R-HSA-216083 Reactome: R-HSA-3000157 Reactome: R-HSA-3000171 Reactome: R-HSA-3000178 Reactome: R-HSA-3560783 Reactome: R-HSA-3560801 Reactome: R-HSA-3656237 Reactome: R-HSA-3656253 Reactome: R-HSA-4420332 Reactome: R-HSA-9694614 Reactome: R-HSA-975634 Reactome: R-HSA-977225 Reactome: R-HSA-9820960 Reactome: R-HSA-9833110 |
Cellular Localisation | Secreted Extracellular Space Extracellular Matrix Basement Membrane |
Alternative Antibody Names | Anti-Basement Membrane-Specific Heparan Sulfate Proteoglycan Core Protein antibody Anti-Hspg antibody Anti-Perlecan antibody Anti-Plc Cleaved Into - Endorepellin - Lg3 Peptide antibody Anti-HSPG2 antibody |
Information sourced from Uniprot.org