• Western blot analysis of lysates from K562 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-HSD17B12 antibody (STJ190810)

SKU:
STJ190810

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Very-long-chain 3-oxoacyl-CoA reductase is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HSD17B12
Gene ID: 51144
Uniprot ID: DHB12_HUMAN
Specificity: DHB12 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Function Catalyzes the second of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme has a 3-ketoacyl-CoA reductase activity, reducing 3-ketoacyl-CoA to 3-hydroxyacyl-CoA, within each cycle of fatty acid elongation. Thereby, it may participate in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May also catalyze the transformation of estrone (E1) into estradiol (E2) and play a role in estrogen formation.
Protein Name Very-Long-Chain 3-Oxoacyl-Coa Reductase
17-Beta-Hydroxysteroid Dehydrogenase 12
17-Beta-Hsd 12
3-Ketoacyl-Coa Reductase
Kar
Estradiol 17-Beta-Dehydrogenase 12
Short Chain Dehydrogenase/Reductase Family 12c Member 1
Database Links Reactome: R-HSA-193048
Reactome: R-HSA-75876
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Very-Long-Chain 3-Oxoacyl-Coa Reductase antibody
Anti-17-Beta-Hydroxysteroid Dehydrogenase 12 antibody
Anti-17-Beta-Hsd 12 antibody
Anti-3-Ketoacyl-Coa Reductase antibody
Anti-Kar antibody
Anti-Estradiol 17-Beta-Dehydrogenase 12 antibody
Anti-Short Chain Dehydrogenase/Reductase Family 12c Member 1 antibody
Anti-HSD17B12 antibody
Anti-SDR12C1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance