| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HR |
| Gene ID: | 55806 |
| Uniprot ID: | HAIR_HUMAN |
| Immunogen Region: | 200-480 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 200-480 of human HR (NP_005135.2). |
| Immunogen Sequence: | SLGSKGFYYKDPSIPRLAKE PLAAAEPGLFGLNSGGHLQR AGEAERPSLHQRDGEMGAGR QQNPCPLFLGQPDTVPWTSW PACPPGLVHTLGNVWAGPGD GNLGYQLGPPATPRCPSPEP PVTQRGCCSSYPPTKGGGLG PCGKCQEGLEGGASGASEPS EEVNKASGPRACPPSHHTKL KKTWLTRHSEQFECPRGCPE VEERPVARLRALKRAGSPEV QGAMGSPAPKRPPDPFPGT |
| Tissue Specificity | Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis. Isoform 2 is exclusively expressed at high levels in the skin. |
| Function | Histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. May act as a transcription regulator controlling hair biology (via targeting of collagens), neural activity, and cell cycle. |
| Protein Name | Lysine-Specific Demethylase HairlessHistone H3-Dimethyl-L-Lysine(9 Demethylase Hairless |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Lysine-Specific Demethylase Hairless antibodyAnti-Histone H3-Dimethyl-L-Lysine(9 Demethylase Hairless antibodyAnti-HR antibody |
Information sourced from Uniprot.org