Anti-HPK1/MAP4K1 antibody (N-Term) (STJ70186)

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STJ70186-100
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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human/Mouse/Rat/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Goat polyclonal antibody anti-HPK1/MAP4K1 (N-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:32000.
WB: Approx 95-100kDa band observed in Jurkat (predicted MW of 96kDa according to NP_009112). Recommended for use at 0.5-2µg/ml.
IHC: Paraffin embedded Human Thymus. Recommended concent
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: MAP4K1
Gene ID: 11184
Uniprot ID: M4K1_HUMAN
Immunogen Region: N-Term
Accession Number: NP_001036065.1; NP_009112.1
Specificity: This antibody is expected to recognise isoform 1 (NP_001036065.1) and isoform 2 (NP_009112.1).
Immunogen Sequence: DVVDPDIFNRDPR
Post Translational Modifications Autophosphorylates: phosphorylation promotes ubiquitination by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex, leading to its degradation by the proteasome. Tyrosine-phosphorylated after activation of hemopoietic cells. Ubiquitinated by the Cul7-RING(FBXW8) ubiquitin-protein ligase complex following autophosphorylation, leading to its degradation by the proteasome.
Function Serine/threonine-protein kinase, which plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. May play a role in hematopoietic lineage decisions and growth regulation. Together with CLNK, it enhances CD3-triggered activation of T-cells and subsequent IL2 production.
Protein Name Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1
Hematopoietic Progenitor Kinase
Mapk/Erk Kinase Kinase Kinase 1
Mek Kinase Kinase 1
Mekkk 1
Alternative Antibody Names Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 antibody
Anti-Hematopoietic Progenitor Kinase antibody
Anti-Mapk/Erk Kinase Kinase Kinase 1 antibody
Anti-Mek Kinase Kinase 1 antibody
Anti-Mekkk 1 antibody
Anti-MAP4K1 antibody
Anti-HPK1 antibody

Information sourced from Uniprot.org