• Western blot analysis of lysates from HeLa, Jurkat, and HUVEC cells, using hnRNP L Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using hnRNP L Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of HuvEc cells using hnRNP L Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).
  • Immunofluorescence analysis of HeLa cells, using hnRNP L Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using hnRNP L Polyclonal Antibody cells nucleus extracted by Minute TM Cytoplasmic and Nuclear Fractionation kit (SC-003, Inventbiotech, MN, USA).

Anti-HNRNPL antibody (61-110 aa) (STJ93568)

SKU:
STJ93568

£48.00 - £252.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Heterogeneous nuclear ribonucleoprotein L (61-110 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: HNRNPL
Gene ID: 3191
Uniprot ID: HNRPL_HUMAN
Immunogen Region: 61-110 aa
Specificity: hnRNP L Polyclonal Antibody detects endogenous levels of hnRNP L protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human hnRNP L at the amino acid range 61-110
Function Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8.
Protein Name Heterogeneous Nuclear Ribonucleoprotein L
Hnrnp L
Database Links Reactome: R-HSA-72163
Reactome: R-HSA-72203
Cellular Localisation Nucleus
Nucleoplasm
Cytoplasm
Localized In Cytoplasmic Mrnp Granules Containing Untranslated Mrnas
These Granules Are Not Identical With P Bodies Or Stress Granules
Alternative Antibody Names Anti-Heterogeneous Nuclear Ribonucleoprotein L antibody
Anti-Hnrnp L antibody
Anti-HNRNPL antibody
Anti-HNRPL antibody
Anti-P antibody
Anti-OKcl.14 antibody

Information sourced from Uniprot.org

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