| Tissue Specificity | Expressed in testis, skeletal muscle, thymus, prostate, colon, peripheral blood cells, brain and placenta. |
| Function | Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation. |
| Protein Name | Jupiter Microtubule Associated Homolog 1Androgen-Regulated Protein 2Hematological And Neurological Expressed 1 Protein Cleaved Into - Jupiter Microtubule Associated Homolog 1 - N-Terminally Processed |
| Database Links | |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Jupiter Microtubule Associated Homolog 1 antibodyAnti-Androgen-Regulated Protein 2 antibodyAnti-Hematological And Neurological Expressed 1 Protein Cleaved Into - Jupiter Microtubule Associated Homolog 1 - N-Terminally Processed antibodyAnti-JPT1 antibodyAnti-ARM2 antibodyAnti-HN1 antibody |
Information sourced from Uniprot.org
