| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Hydroxymethylglutaryl-CoA synthase, mitochondrial is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HMGCS2 |
| Gene ID: | 3158 |
| Uniprot ID: | HMCS2_HUMAN |
| Specificity: | This antibody detects endogenous levels of HMGCS2 at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human HMGCS2 |
| Post Translational Modifications | Succinylated. Desuccinylated by SIRT5. Succinylation, at least at Lys-83 and Lys-310, inhibits the enzymatic activity. |
| Function | Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate. |
| Protein Name | Hydroxymethylglutaryl-Coa Synthase - MitochondrialHmg-Coa Synthase3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-77111Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Hydroxymethylglutaryl-Coa Synthase - Mitochondrial antibodyAnti-Hmg-Coa Synthase antibodyAnti-3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase antibodyAnti-HMGCS2 antibody |
Information sourced from Uniprot.org