| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HMBS (1-361) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HMBS |
| Gene ID: |
3145 |
| Uniprot ID: |
HEM3_HUMAN |
| Immunogen Region: |
1-361 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human HMBS (NP_000181.2). |
| Immunogen Sequence: |
MSGNGNAAATAEENSPKMRV IRVGTRKSQLARIQTDSVVA TLKASYPGLQFEIIAMSTTG DKILDTALSKIGEKSLFTKE LEHALEKNEVDLVVHSLKDL PTVLPPGFTIGAICKRENPH DAVVFHPKFVGKTLETLPEK SVVGTSSLRRAAQLQRKFPH LEFRSIRGNLNTRLRKLDEQ QEFSAIILATAGLQRMGWHN RVGQILHPEECMYAVGQGAL GVEVRAKDQDILDLVGVLH |
| Tissue Specificity | Isoform 1: Is ubiquitously expressed. Isoform 2: Is found only in erythroid cells. |
| Function | As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact. |
| Protein Name | Porphobilinogen DeaminasePbg-DHydroxymethylbilane SynthaseHmbsPre-Uroporphyrinogen Synthase |
| Database Links | Reactome: R-HSA-189451 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Porphobilinogen Deaminase antibodyAnti-Pbg-D antibodyAnti-Hydroxymethylbilane Synthase antibodyAnti-Hmbs antibodyAnti-Pre-Uroporphyrinogen Synthase antibodyAnti-HMBS antibodyAnti-PBGD antibodyAnti-UPS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
