Anti-HMB45 antigen antibody [HMB45] (STJ16101748)

Anti-HMB45 antigen antibody [HMB45] (STJ16101748)

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STJ16101748-1
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-HMB45 antigen (Melanoma Marker) is suitable for use in Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : HMB45
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: Tissue culture supernatant with Sodium azide
Concentration: >=10.8 mg/L
Dilution Range: IHC-P 1:60
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: Extract of pigmented melanoma metastases from lymph nodes.
Background The HMB45 antigen has also been identified in retinal pigment epithelium (RPE) but is reported to be reactive only with the transient prenatal and infantile RPE. No reaction is reported to be observed with intradermal nevi and normal adult melanocytes and non-melanocytic cells. Tumor cells of epithelial, lymphoid, glial and mesenchymal origin are reported to be negative. This clone is well described in the literature. It is indicated to label an intracytoplasmic antigen in the majority of melanomas and other tumors demonstrating melanoma/melanocytic differentiation. The clone is also reported to react with junctional and blue nevus cells. (Bacchi CE et al., A Review. Applied Immunohistochemistry. 4:73-85 (1996) ).

Information sourced from Uniprot.org

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