Anti-HM13 antibody (STJA0008268)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SPP
General Information
| Short Description | Rabbit polyclonal anti-Minor histocompatibility antigen H13 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | HM13 |
| Gene ID | 81502 |
| Uniprot ID | SPP_HUMAN |
| Immunogen | Synthesized peptide derived from human SPP |
| Specificity | This antibody detects endogenous levels of SPP at Human, Mouse |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes intramembrane proteolysis of signal peptides that have been removed from precursors of secretory and membrane proteins, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner. May play a role in graft rejection. |
| Protein Name | Signal Peptide PeptidaseIntramembrane Protease 1Imp-1Impas-1Himp1Minor Histocompatibility Antigen H13Presenilin-Like Protein 3Signal Peptide Peptidase-Like 1 |
| Database Links | Reactome: R-HSA-9707587 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMembraneLumenal SideIsoform 4: Cell Membrane |
| Alternative Antibody Names | Anti-Signal Peptide Peptidase antibodyAnti-Intramembrane Protease 1 antibodyAnti-Imp-1 antibodyAnti-Impas-1 antibodyAnti-Himp1 antibodyAnti-Minor Histocompatibility Antigen H13 antibodyAnti-Presenilin-Like Protein 3 antibodyAnti-Signal Peptide Peptidase-Like 1 antibodyAnti-HM13 antibodyAnti-H13 antibodyAnti-IMP1 antibodyAnti-PSL3 antibodyAnti-SPP antibodyAnti-MSTP086 antibody |
Information sourced from Uniprot.org