| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Minor histocompatibility antigen H13 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HM13 |
| Gene ID: |
81502 |
| Uniprot ID: |
HM13_HUMAN |
| Specificity: |
This antibody detects endogenous levels of SPP at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human SPP |
| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner. May play a role in graft rejection. |
| Protein Name | Minor Histocompatibility Antigen H13Intramembrane Protease 1Imp-1Impas-1Himp1Presenilin-Like Protein 3Signal Peptide Peptidase |
| Database Links | Reactome: R-HSA-9707587 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMembraneLumenal SideIsoform 4: Cell Membrane |
| Alternative Antibody Names | Anti-Minor Histocompatibility Antigen H13 antibodyAnti-Intramembrane Protease 1 antibodyAnti-Imp-1 antibodyAnti-Impas-1 antibodyAnti-Himp1 antibodyAnti-Presenilin-Like Protein 3 antibodyAnti-Signal Peptide Peptidase antibodyAnti-HM13 antibodyAnti-H13 antibodyAnti-IMP1 antibodyAnti-PSL3 antibodyAnti-SPP antibodyAnti-MSTP086 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
