| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes intramembrane proteolysis of signal peptides that have been removed from precursors of secretory and membrane proteins, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner. May play a role in graft rejection. |
| Protein Name | Signal Peptide PeptidaseIntramembrane Protease 1Imp-1Impas-1Himp1Minor Histocompatibility Antigen H13Presenilin-Like Protein 3Signal Peptide Peptidase-Like 1 |
| Database Links | Reactome: R-HSA-9707587 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMembraneLumenal SideIsoform 4: Cell Membrane |
| Alternative Antibody Names | Anti-Signal Peptide Peptidase antibodyAnti-Intramembrane Protease 1 antibodyAnti-Imp-1 antibodyAnti-Impas-1 antibodyAnti-Himp1 antibodyAnti-Minor Histocompatibility Antigen H13 antibodyAnti-Presenilin-Like Protein 3 antibodyAnti-Signal Peptide Peptidase-Like 1 antibodyAnti-HM13 antibodyAnti-H13 antibodyAnti-IMP1 antibodyAnti-PSL3 antibodyAnti-SPP antibodyAnti-MSTP086 antibody |
Information sourced from Uniprot.org
