| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1. Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner. May play a role in graft rejection. |
| Protein Name | Minor Histocompatibility Antigen H13Intramembrane Protease 1Imp-1Impas-1Himp1Presenilin-Like Protein 3Signal Peptide Peptidase |
| Database Links | Reactome: R-HSA-9707587 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMembraneLumenal SideIsoform 4: Cell Membrane |
| Alternative Antibody Names | Anti-Minor Histocompatibility Antigen H13 antibodyAnti-Intramembrane Protease 1 antibodyAnti-Imp-1 antibodyAnti-Impas-1 antibodyAnti-Himp1 antibodyAnti-Presenilin-Like Protein 3 antibodyAnti-Signal Peptide Peptidase antibodyAnti-HM13 antibodyAnti-H13 antibodyAnti-IMP1 antibodyAnti-PSL3 antibodyAnti-SPP antibodyAnti-MSTP086 antibody |
Information sourced from Uniprot.org
