| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HLA-DMA (27-233) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HLA-DMAUniprot ID=DMA_HUMAN" |
| Immunogen Region: |
27-233 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 27-233 of human HLA-DMA (NP_006111.2). |
| Immunogen Sequence: |
VPEAPTPMWPDDLQNHTFLH TVYCQDGSPSVGLSEAYDED QLFFFDFSQNTRVPRLPEFA DWAQEQGDAPAILFDKEFCE WMIQQIGPKLDGKIPVSRGF PIAEVFTLKPLEFGKPNTLV CFVSNLFPPMLTVNWQHHSV PVEGFGPTFVSAVDGLSFQA FSYLNFTPEPSDIFSCIVTH EIDRYTAIAYWVPRNALPSD LLENVLC |
| Function | Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. |
| Protein Name | Hla Class Ii Histocompatibility Antigen - Dm Alpha ChainMhc Class Ii Antigen DmaReally Interesting New Gene 6 Protein |
| Cellular Localisation | Late Endosome MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneLocalizes To Late Endocytic CompartmentAssociates With Lysosome Membranes |
| Alternative Antibody Names | Anti-Hla Class Ii Histocompatibility Antigen - Dm Alpha Chain antibodyAnti-Mhc Class Ii Antigen Dma antibodyAnti-Really Interesting New Gene 6 Protein antibodyAnti-HLA-DMA antibodyAnti-DMA antibodyAnti-RING6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
