| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Other |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | H1-0 |
| Gene ID: | 3005 |
| Uniprot ID: | H10_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Histone H1.0 (P07305). |
| Immunogen Sequence: | MTENSTSAPAAKPKRAKASK KSTDHPKYSDMIVAAIQAEK NRAGSSRQSIQKYIKSHYKV GENADSQIKLSIKRLVTTGV LKQTKGVGASGSFRLAKSDE |
| Post Translational Modifications | Phosphorylated on Ser-17 in RNA edited version. ADP-ribosylated on Ser-104 in response to DNA damage. |
| Function | Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division. |
| Protein Name | Histone H1.0Histone H1'Histone H1(0 Cleaved Into - Histone H1.0 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-140342Reactome: R-HSA-2559584 |
| Cellular Localisation | NucleusChromosomeThe Rna Edited Version Has Been Localized To Nuclear SpecklesDuring MitosisIt Appears In The Vicinity Of Condensed Chromosomes |
| Alternative Antibody Names | Anti-Histone H1.0 antibodyAnti-Histone H1' antibodyAnti-Histone H1(0 Cleaved Into - Histone H1.0 - N-Terminally Processed antibodyAnti-H1-0 antibodyAnti-H1F0 antibodyAnti-H1FV antibody |
Information sourced from Uniprot.org