| Post Translational Modifications | Autophosphorylated, but autophosphorylation is not required for catalytic activity. May be sumoylated. |
| Function | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). |
| Protein Name | Homeodomain-Interacting Protein Kinase 3Androgen Receptor-Interacting Nuclear Protein KinaseAnpkFas-Interacting Serine/Threonine-Protein KinaseFistHomolog Of Protein Kinase Yak1 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Homeodomain-Interacting Protein Kinase 3 antibodyAnti-Androgen Receptor-Interacting Nuclear Protein Kinase antibodyAnti-Anpk antibodyAnti-Fas-Interacting Serine/Threonine-Protein Kinase antibodyAnti-Fist antibodyAnti-Homolog Of Protein Kinase Yak1 antibodyAnti-HIPK3 antibodyAnti-DYRK6 antibodyAnti-FIST3 antibodyAnti-PKY antibody |
Information sourced from Uniprot.org
