| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Homeodomain-interacting protein kinase 3 (770-850 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HIPK3 |
| Gene ID: |
10114 |
| Uniprot ID: |
HIPK3_HUMAN |
| Immunogen Region: |
770-850 aa |
| Specificity: |
HIPK3 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 770-850 |
| Post Translational Modifications | Autophosphorylated, but autophosphorylation is not required for catalytic activity. May be sumoylated. |
| Function | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). |
| Protein Name | Homeodomain-Interacting Protein Kinase 3Androgen Receptor-Interacting Nuclear Protein KinaseAnpkFas-Interacting Serine/Threonine-Protein KinaseFistHomolog Of Protein Kinase Yak1 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Homeodomain-Interacting Protein Kinase 3 antibodyAnti-Androgen Receptor-Interacting Nuclear Protein Kinase antibodyAnti-Anpk antibodyAnti-Fas-Interacting Serine/Threonine-Protein Kinase antibodyAnti-Fist antibodyAnti-Homolog Of Protein Kinase Yak1 antibodyAnti-HIPK3 antibodyAnti-DYRK6 antibodyAnti-FIST3 antibodyAnti-PKY antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
