| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HIP1R |
| Gene ID: | 9026 |
| Uniprot ID: | HIP1R_HUMAN |
| Immunogen Region: | 300-600 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-600 of human HIP1R (NP_003950.1). |
| Immunogen Sequence: | KPVVVIPEEAPEDEEPENLI EISTGPPAGEPVVVADLFDQ TFGPPNGSVKDDRDLQIESL KREVEMLRSELEKIKLEAQR YIAQLKSQVNALEGELEEQR KQKQKALVDNEQLRHELAQL RAAQLEGERSQGLREEAERK ASATEARYNKLKEKHSELVH VHAELLRKNADTAKQLTVTQ QSQEEVARVKEQLAFQVEQV KRESELKLEEKSDQLEKLKR ELEAKAGELARAQEALSHT |
| Tissue Specificity | Brain, heart, kidney, pancreas, and liver, but not in lung or placenta. |
| Function | Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. |
| Protein Name | Huntingtin-Interacting Protein 1-Related ProteinHip1-Related ProteinHuntingtin-Interacting Protein 12Hip-12 |
| Database Links | Reactome: R-HSA-432722Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmPerinuclear RegionEndomembrane SystemCytoplasmic VesicleClathrin-Coated Vesicle MembraneMembrane-Associated ProteinMainly Localized At The Endocytic Compartments And In The Perinuclear Region |
| Alternative Antibody Names | Anti-Huntingtin-Interacting Protein 1-Related Protein antibodyAnti-Hip1-Related Protein antibodyAnti-Huntingtin-Interacting Protein 12 antibodyAnti-Hip-12 antibodyAnti-HIP1R antibodyAnti-HIP12 antibodyAnti-KIAA0655 antibody |
Information sourced from Uniprot.org