| Tissue Specificity | Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts. |
| Post Translational Modifications | Glycosylated. |
| Function | Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. |
| Protein Name | Transmembrane Prolyl 4-HydroxylaseP4h-TmHypoxia-Inducible Factor Prolyl Hydroxylase 4Hif-Ph4Hif-Prolyl Hydroxylase 4Hph-4 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Transmembrane Prolyl 4-Hydroxylase antibodyAnti-P4h-Tm antibodyAnti-Hypoxia-Inducible Factor Prolyl Hydroxylase 4 antibodyAnti-Hif-Ph4 antibodyAnti-Hif-Prolyl Hydroxylase 4 antibodyAnti-Hph-4 antibodyAnti-P4HTM antibodyAnti-PH4 antibody |
Information sourced from Uniprot.org
