| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HHLA2 |
| Gene ID: | 11148 |
| Uniprot ID: | HHLA2_HUMAN |
| Immunogen Region: | 30-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-200 of human HHLA2 (NP_009003.1). |
| Immunogen Sequence: | IYVPMNEQIVIGRLDEDIIL PSSFERGSEVVIHWKYQDSY KVHSYYKGSDHLESQDPRYA NRTSLFYNEIQNGNASLFFR RVSLLDEGIYTCYVGTAIQV ITNKVVLKVGVFLTPVMKYE KRNTNSFLICSVLSVYPRPI ITWKMDNTPISENNMEETGS LDSFSINSPLN |
| Tissue Specificity | Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B-cells, dendritic cells and macrophages. Not detected in T-cells. |
| Function | Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. |
| Protein Name | Herv-H Ltr-Associating Protein 2Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Herv-H Ltr-Associating Protein 2 antibodyAnti-Human Endogenous Retrovirus-H Long Terminal Repeat-Associating Protein 2 antibodyAnti-HHLA2 antibody |
Information sourced from Uniprot.org