| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HJV |
| Gene ID: | 148738 |
| Uniprot ID: | RGMC_HUMAN |
| Immunogen Region: | 1-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-174 of human HFE2 (NP_998817.1). |
| Immunogen Sequence: | MQECIDQKVYQAEVDNLPVA FEDGSINGGDRPGGSSLSIQ TANPGNHVEIQAAYIGTTII IRQTAGQLSFSIKVAEDVAM AFSAEQDLQLCVGGCPPSQR LSRSERNRRGAITIDTARRL CKEGLPVEDAYFHSCVFDVL ISGDPNFTVAAQAALEDARA FLPDLEKLHLFPSD |
| Tissue Specificity | Adult and fetal liver, heart, and skeletal muscle. |
| Post Translational Modifications | Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. Also proteolytically processed by TMPRSS6, several fragments being released in the extracellular space.regulates HJV activity in BMP signaling and thefore iron homeostasis. |
| Function | Acts as a bone morphogenetic protein (BMP) coreceptor. Through enhancement of BMP signaling regulates hepcidin (HAMP) expression and regulates iron homeostasis. |
| Protein Name | HemojuvelinHemochromatosis Type 2 ProteinHemojuvelin Bmp CoreceptorRgm Domain Family Member C |
| Database Links | Reactome: R-HSA-373752 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorAlso Released In The Extracellular Space |
| Alternative Antibody Names | Anti-Hemojuvelin antibodyAnti-Hemochromatosis Type 2 Protein antibodyAnti-Hemojuvelin Bmp Coreceptor antibodyAnti-Rgm Domain Family Member C antibodyAnti-HJV antibodyAnti-HFE2 antibodyAnti-RGMC antibody |
Information sourced from Uniprot.org