| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HFE |
| Gene ID: | 3077 |
| Uniprot ID: | HFE_HUMAN |
| Immunogen Region: | 80-306 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-306 of human HFE (NP_000401.1). |
| Immunogen Sequence: | SSQMWLQLSQSLKGWDHMFT VDFWTIMENHNHSKESHTLQ VILGCEMQEDNSTEGYWKYG YDGQDHLEFCPDTLDWRAAE PRAWPTKLEWERHKIRARQN RAYLERDCPAQLQQLLELGR GVLDQQVPPLVKVTHHVTSS VTTLRCRALNYYPQNITMKW LKDKQPMDAKEFEPKDVLPN GDGTYQGWITLAVPPGEEQR YTCQVEHPGLDQPLIVIWEP SPSGTLV |
| Tissue Specificity | Expressed in all tissues tested except brain. |
| Function | Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. |
| Protein Name | Hereditary Hemochromatosis ProteinHla-H |
| Database Links | Reactome: R-HSA-917977 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Hereditary Hemochromatosis Protein antibodyAnti-Hla-H antibodyAnti-HFE antibodyAnti-HLAH antibody |
Information sourced from Uniprot.org